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Publications

YAP and TAZ regulate remyelination in the central nervous system.  Hong, J, J.M. Kirkland, J. Acheta, N. Marziali Leandro, B. Beck, J. Haley, U. Bhatia, G. Davis, J. Herron, C. Abi-Ghanem, M.L. Feltri, K. Zuloaga, M.E. Bechler, Y. Poitelon, S. Belin. 2024. Glia. 72(1):156-166.
doi: 10.1002/glia.24467

Selective PDE4 Subtype Inhibition Provides New Opportunities to Intervene in Neuroinflammatory Versus Myelin Damaging Hallmarks of Multiple Sclerosis. Schepers, M, D. Paes, A. Tiane, B. Rombaut, E. Piccart, L. van Veggel, P. Gervois, E. Wolfs, I. Lambrichts, C. Brullo, O. Bruno, E. Fedele, R. Ricciarelli, C. ffrench-Constant, M.E. Bechler, P. van Schaik, W. Baron, E. Lefevere, K. Wasner, A. Grünewald, C. Verfaillie, P. Baeten, B. Broux, P. Wieringa, N. Hellings, J. Prickaerts, and T. Vanmierlo. 2022. Brain Behav Immun. 109:1-22.
doi: 10.1016/j.bbi.2022.12.020.

Biomimicking Fiber Platform with Tunable Stiffness to Study Mechanotransduction Reveals Stiffness Enhances Oligodendrocyte Differentiation but Impedes Myelination through YAP-dependent Regulation. Ong, W., N. Marinval, J. Lin, M.H. Nai, Y.-S. Chong, C. Pinese, S. Sajikumar, C.T. Lim, C. ffrench-Constant, M.E. Bechler, and S.Y. Chew. 2020. Small. 16(37): 2003656.
doi:10.1002/smll.202003656

A Neuron-free Microfiber Assay to Assess Myelin Sheath Formation.

M.E. Bechler. 2019. Methods in Molecular Biology. Oligodendrocytes: Methods and Protocols. Eds. D. Lyons and L. Kegel, Springer. 1936: 97-110. 
doi: 10.1007/978-1-4939-9072-6_6

Scaffold-Mediated Sustained, Non-Viral Delivery of miR-219/miR-338 Promotes CNS Remyelination.

Milbreta, U*., J. Lin*, C. Pinese, W. Ong, J.S. Chin, H. Shirahama, R. Mi, A. Williams, M.E. Bechler, J. Wang, C. ffrench-Constant, A. Hoke, and S.Y. Chew. 2019. Mol Ther. 27(2):411-423. 
doi:10.1016/j.ymthe.2018.11.016

Microfiber Drug/Gene Delivery Platform for Study of Myelination.

Ong, W., J. Lin, M.E. Bechler, K. Wang, M. Wang, C. ffrench-Constant, and S.Y. Chew. 2018. Acta Biomaterialia. 75:152-160. 
doi:10.1016/j.actbio.2018.06.011

Activin Receptors Regulate the Oligodendrocyte Lineage in Health and Disease.

Dillenburg, A., G. Ireland, R.K. Holloway, C.L. Davies, F.L. Evans, M. Swire, M.E. Bechler, D. Soong, T.J. Yuen, G.H. Su, J.C. Becher, C. Smith, A. Williams, and V.E. Miron. 2018. Acta Nuropathol. 135(6):887-906. 
doi:10.1007/s00401-018-1813-3

Intrinsic and Adaptive Myelination – a Sequential Mechanism for Smart Wiring in the Brain.

Bechler, M.E., M. Swire, and C. ffrench-Constant. 2018. Dev Neurobiol. 78(2): 68-79
doi:10.1002/dneu.22518 

Reconstitution of Phospholipase A2-Dependent Golgi Membrane Tubules.

Cluett, E.B., P. de Figueiredo, M.E. Bechler, K.D. Thorsen, and W.J. Brown. 2016. Methods in Molecular Biology. The Golgi Complex: Methods and Protocols. Ed. W. Brown, Springer. 1496: 75-90. 
doi:10.1007/978-1-4939-6463-5_7

CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes.

Bechler, M.E., L. Byrne, and C. ffrench-Constant. 2015. Curr Biol. 25(18): 2411-2416. 
doi:10.1016/j.cub.2015.07.056

A New Wrap for Neuronal Activity?
Bechler, M.E. and C. ffrench-Constant. 2014. Science. 344(6183): 480-481. 
doi:10.1126/science.1254446

Gβ1γ2 Activates Phospholipase A2-Dependent Golgi Membrane Tubule Formation.
Bechler, M.E. and W.J. Brown. 2014. Front Cell Dev Biol. 2(4). 

doi:10.3389/fcell.2014.00004

PAFAH Ib Phospholipase A2 Subunits Have Distinct Roles in Maintaining Golgi Structure and Function.
Bechler, M.E. and W.J. Brown.  2013. Biochim Biophys Acta. 1831: 595-601.  
doi:10.1016/j.bbalip.2012.12.004

A PLA1-2 Punch Regulates the Golgi Complex.  
Bechler, M.E., P. de Figueiredo and W.J. Brown.  2011. Trends Cell Biol. 22: 1–9. 
doi:10.1016/j.tcb.2011.10.003

The Phospholipase A2 Enzyme Complex PAFAH Ib Mediates Endosomal Membrane Tubule Formation and Trafficking.  
Bechler, M.E., A.M. Doody, K.D. Ha, B.L. Judson, I. Chen, and W.J. Brown. 2011. Mol Biol Cell. 22: 2348–2359. 
doi:10.1091/mbc.E09-12-1064

The Phospholipase Complex PAFAH Ib Regulates the Functional Organization of the Golgi Complex.

Bechler, M.E.*, A.M. Doody*, E. Racoosin, L. Lin, K. Lee and W.J. Brown.  2010. J Cell Biol. 190: 45-53. 
doi:10.1083/jcb.200908105

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